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Wegovy side effects

It’s important to know that Wegovy treatment can cause potential side effects in patients, including serious allergic reaction. You should be aware of these before taking the medicine, so you can be prepared and treat any symptoms that may occur.


What is Wegovy?

Wegovy (semaglutide) injection 2.4 mg is the brand name for the NICE and FDA approved injectable prescription drug for chronic weight management.

It’s used for adults with obesity (BMI ≥30), or who are overweight (excess weight) (BMI ≥27), or those with a weight related comorbid condition, to help them lose weight and keep the weight off.

The bottom line upfront:

  • Wegovy should be used in conjunction with a reduced calorie meal plan and increased exercise.

  • Wegovy contains semaglutide and therefore patients should not take it if they’re taking other semaglutide-containing products, or any other GLP-1 receptor agonist medications.

  • It is not known if Wegovy is safe to take with prescription, or over-the-counter medicines, or herbal weight loss products.

Common adverse reactions when taking Wegovy

Many people tolerate Wegovy well, but you’re likely to experience side effects at some point while taking it.

In clinical trials, 6.8% of patients taking Wegovy and 3.2% of patients taking placebo permanently discontinued treatment.

This was because a gastrointestinal adverse reaction occurred.

The most common side effects of Wegovy included nausea and vomiting, which we’ll discuss later on in this article.

However, there are also less common and more serious side effects with Wegovy that you should know about, and we’ll also discuss these in detail.

If you have any concerns or questions about the possible side effects of Wegovy, talk with us, your doctor or pharmacist immediately.

The most common adverse reactions to Wegovy

The most common Wegovy side effects are:

  • Injection site reactions

  • Headache

  • Nausea

  • Abdominal pain

  • Insomnia

  • Vomiting

  • Diarrhea

  • Joint pain

Most of these side effects will disappear on their own, but if they don’t and they’re bothering you, talk with your doctor or pharmacist.

Tips for how to manage nausea from Wegovy

Nausea is the most common side effect from taking Wegovy, here’s how you can manage this symptom:

  • Try to take your medication with food. If you normally take it on an empty stomach and suffer with nausea, try taking it after a meal or snack so that the nausea will be less pronounced.

  • Rest if possible. Avoid exercising during times of severe nausea (this might mean letting go of a workout for a few days), as exercise can make symptoms worse in some cases.

  • Drink liquids liberally if possible and eat small amounts of bland foods, like crackers or toast as these foods are more likely to stay down when you’re feeling nauseated.

Allergic reactions when taking Wegovy

Serious allergic reactions to Wegovy use are rare. However, you should be aware that they exist and seek immediate medical attention if you experience any of them:

  • Angioedema – swelling of the face, lips, tongue or throat

  • Difficulty breathing or wheezing (breathing with a whistling sound)

  • Fainting

  • Chest pain

  • Hives (itches) or skin rash (with or without swelling)

Tell your doctor if you develop any signs and symptoms of a rash (including hives, itching) or skin reactions such as a rash or peeling of the skin.

They may be due to an allergic reaction to Wegovy or another medicine you’re taking together with Wegovy, such as ibuprofen.

If it’s hard for you to tell whether a rash is from the drug or something else, talk with your doctor about whether there are other things that could cause your symptoms (such as sunburn).

Your healthcare provider might be able to give you advice on how to avoid getting rashes while still taking

Other serious side effects from Wegovy

Wegovy can cause a variety of reactions, but you should contact your doctor right away if you experience any of the serious side effects:

Severe adverse gastrointestinal reactions

Acute kidney injury

Acute kidney injury is typically sudden. Symptoms include:

  • dark urine

  • nausea

  • swelling in the lower limbs

  • less frequent urination

Acute gallbladder disease

Gallbladder problems are a serious side effect of Wegovy. Symptoms include:

  • Persistent severe abdominal pain

  • Jaundice

  • Dark urine

  • Loss of appetite

If you experience any of these side effects talk to your healthcare provider and they’ll carry out tests for these conditions. They’ll also be able to tell you whether it’s safe to carry on taking these weight loss drugs.

Diabetic retinopathy

This renal impairment blood vessel damage in the eyes and can be as a result of diabete. Symptoms include:

  • blurred vision

  • eye floaters

  • vision loss

  • colour blindness

Severe hypoglycemia (low blood sugar)

Patients with type 2 diabetes can experience low blood sugar when taking Wegovy. Symptoms include:

  • blurred vision

  • lightheadedness

  • shaking

  • sweaty

  • feeling weak


It is not known if Wegovy is safe to be taken by patients with a history of pancreatitis.

The most important side effect details of Wegovy

This is the most important information you need to know about are further details about taking this medicine and the potential side effects you should be aware of.

Increased risk of thyroid cancer, including thyroid c cell tumors

If you take Wegovy there is an increased risk of thyroid c cell tumors developing.

In trials carried out on rats, the animals that were give the drug developed an increase risk of thyroid cancer. While it isn’t known for sure if this risk applies to treated patients, it’s something to be aware of.

Medullary Thyroid Carcinoma (MTC)

If you have personal or family history of Medullary Thyroid Carcinoma (MTC), you are advised NOT TO TAKE Wegovy to aid weight loss.

Endocrine Neoplasia Syndrome type 2 (MEN)

You also should not take or be prescribed Wegovy if you have endocrine neoplasia syndrome type 2 (MEN). This is a rare condition that can result in thyroid cancer.

If you experience hoarseness or a sore throat that lasts for several days after your treatment is finished, you should contact your doctor or pharmacist right away.

Serious allergic reactions

Do not take Wegovy if you have ever had serious hypersensitivity reactions occur after taking semaglutide, or any other ingredients listed in Wegovy.

Learn More


If you’ve been prescribed Wegovy for weight loss and you have any questions or concerns about your medication, be sure to speak with your doctor. They can provide more information on how this medication works and its potential side effects.